The overarching theme of the MMM2010 conference is "Tackling Materials Complexities via Computational Science." This theme selection reflects the intimate connection between multiscale materials modeling and the wider field of computational science. It also reflects the level of maturity that the field of multiscale materials research has come to. The conference encourages participation from academia, national laboratories, and industrial research facilities worldwide. The conference scope spans topics ranging from basic multiscale modeling principles all the way to computational materials design using the computational tools developed based upon these principles. The conference solicits theoretical, computational, and experimental contributions addressing one or more of the multiscale materials modeling issues.